CSB331H1 Lecture Notes - Lecture 9: Dorsal Consonant, Receptor Tyrosine Kinase, Primitive Streak
11 Mar 2014
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Document Summary
Lecture 9 - dorsal closure in drosophila as a model for wound healing. Using the basic knowledge we learned through in vitro situ and models to understand the complexity of these events. We scar because we have an immune system. In pre natal development you can heal without scarring, because the immune system is not yet developed. Once immune system kicks into place, you get scarring. Keratinocytes move along and myosin motor protein is concentrated in the actin. If you cut yourself (not a massive wound, you can see the wound mesenchyme which is the underlying tissue. And this is under the filtration of the immune system. This is going to reseal and this is a contractile event we are talking about. When we look at embryogenesis, one of the reasons we scar is because we have an immune system. Now people sell bandages that sell immune suppressors. In pre natal development you can still heal without scarring.
