CSB331H1 Lecture Notes - Lecture 9: Pyrene, Amnion, Trophoblast
4 Apr 2012
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Cortactin: coordinating adhesion and the actin cytoskeleton at cellular protrusions. Cell motility and the cytoskeleton 66: 865 873 (2009) Neither cadherins nor integrins act alone in supporting morphogenesis and tissue homeostasis. Instead, they cooperate with intracellular signaling and the cytoskeleton to achieve specific biological outcomes. Cytoskeletal cooperation impinges upon actin filaments, intermediate filaments and microtubules and is regulated by cell signaling. Beyond these broad brush statements, however, we are confronted by the challenge that a bewildering number of cytoskeletal effectors and regulatory signals have been implicated in adhesive interactions. Even without having a comprehensive catalog of these players, the challenge is to identify some guiding principles that can help us parse this diversity. Actin-driven surface protrusions: a functional module common to cell-cell and cell-matrix adhesions: the embarrassment of molecular richness is well exemplified by the functional relationship between adhesion receptors and the actin cytoskeleton. Both classical cadherins and integrins functionally interact with actin.
