CSB331H1 Lecture Notes - Lecture 15: Proceedings Of The National Academy Of Sciences Of The United States Of America, Sox9, Mesenchymal Stem Cell

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Csb311 lecture 15: endochondral ossification: cartilage and bone formation. Endochondral ossification: there are two ways to form a bone. Flat bones of our brain is intramembranous (mesenchymal cell go directly) For a long bone, you form a cartilage skeleton, that will be the blueprint for the shape of your bone. The cartilage also starts out with mesenchymal cell but you got this cartilage intermediate. Tendons and ligaments are holding the bones together. Tendons are bone to muscle; ligaments are bone to bone. Other routes for bone formation: intramembranous ossification (mesenchymal tissue is directly converted to bone); neural crest derived bone: flat bones of the skull. Two basic tissue types: epithelial and connective tissue. Chondrocytes, osteoblasts, fibroblasts are examples of connective tissue cells. Secrete abundant ecm, rich in collagens and reside within their secreted matrix. Pro(cid:448)ide the (cid:271)od(cid:455)"s ar(cid:272)hite(cid:272)tural fra(cid:373)e(cid:449)ork a(cid:374)d tissue shape. Contribute to support and repair of ~ every tissue and organ.

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