CSB351Y1 Lecture Notes - Reoviridae, Rotavirus, Helicase

• School: UTSG
• Department: Cell and Systems Biology
• Course: CSB351Y1
• Professor: Kathleen Hefferon

Document Summary

Reoviruses (respiratory, enteric, orphan) belong to the genus orthoreovirus within the family reoviridae. They are characterised by having double-shelled icosahedral capsids and segmented dsrna genomes. Mammalian reoviruses have ten genomic segments and all share a common complement-fixing antigen. There are eight other genera within the family. Reoviridae, including the rotaviruses and orbiviruses, which infect vertebrates, as well as the. Cypoviruses of insects, and phytoreoviruses and fijiviruses associated with plants. All members of the family have dsrna genomes consisting of 10, 11 or 12 segments. georgetown. edu. In endosomes, virions undergo partial degradation by cathepsins to form infectious subvirion particles (isvps) Disassembly can be viewed using cryoelectron microscopy. Complete reovirus particles consist of an inner protein shell (core) 60 nm in diameter, containing the ten dsrna segments, surrounded by an outer protein shell (outer capsid). Spike-like hemagglutinin (s1) proteins project out of the core at each of the 12 vertices of the core icosahedron.