CSB351Y1 Lecture Notes - Lecture 33: Subacute Sclerosing Panencephalitis, Measles Virus, Mononuclear Phagocyte System
26 May 2018
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Lecture 33: Paramyxovirus II
• Only one serotype of measles, infectious encephalopathy caused by slow persistent form of wild measles virus
( harbored in nervous system)
• Measles one of leading cause of death among children although vaccines available
• Measles associated with persistent infections (subacute sclerosing panencephalitis (SSPE)) differ from lytic
ifetios less RNAs produed aay fro 3’
• Measles is RNA without rtranscriptase – cannot integrate in host genome, need continuous expression (do’t
express symptoms here and accumulate mutations)
• Replication site in UTR or eyes → viraemia → reticuloendothelial system (multiplication by hyperplasia and
multinucleated giant cells in lymphoid organs – fusion of infected with adjacent cells
- Rash of measles due to infection of blood capillaries of skin (host T cells attack and lesion endothelial cells)
• Prevention and control – inactivated and attenuated vaccines used (more effective) with MMR or alone
- No vaccination for infants and immunocompromised but those with good clinical state and children with HIV
should due to severity of disease in these patients
2-rinderpest (morbillivirus)
• Classification – antigenically closely related to human measles virus (-sense enveloped), 200nm diameter (big)
- Measles irus is oly irus i this group to haeagglutiate red lood ad orilliiruses do’t hae
neuroaminidase activity
• Pathology- extremely high mortality rate
Pneumoviruses - Human respiratory syncytial pneumovirus (HRSV)
• History – widespread and highly infectious of childhood respiratory disease, leading cause of bronchiolitis and
pneumonia in infants
• Classification – pneumovirus in paramyxoviridae family, enveloped, nonsegmented, -ssRNA ad do’t hae
neuroaminidase activity
• Tissue tropism and pathology – infection restricted to epithelial respiratory tract in human and animals. HRSV F
protein precursor cleaved and does not appear to be rate limiting factor
- Causes URT with common cold symptoms. Progresses to LRT, bronchitis, pneumonia, rhinorrhea (nasal
discharge), fever, coughing, wheezing, lasts 7-12 days
- Infection due to destruction of epithelial cells by virus replication causing edema, mucus secretion, etc
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