CSB430H1 Lecture 3: Lecture 3.docx
12 Mar 2014
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Document Summary
The anterior/posterior patterning depends on 4 components: gradients of maternal gene products in the egg, define global anterior/posterior axis, gap genes, they occupy big hunks of territory within the developing embryo, receive that name because there are gaps in there expression pattern, subdivide embryo into broad regions, pair rule genes, because they are expressed in pairs of segments, broad stripes define an initial repeat of 2 segments, segment polarity genes, within a segment of the embryo there is an anterior/posterior boundary, these genes specify anterior/posterior boundaries of individual segments, further subdivide segments into compartments. As time passes in the development of these animals, there is more and more refinement of the anterior/posterior: hox genes, are important for specifying particular developmental structures (e. g. eye less specifies which tissue becomes an eye; bithorax and abdominal a specific which region becomes thorax and abdomen, dysregulation of these genes produces interesting phentype.
