HMB200H1 Lecture Notes - Lecture 10: Receptor Antagonist, Thalamus, Implicit Memory
Document Summary
These are homeostatic loops, they happen for a purpose. Feeding is triggered by random internal behaviours like hunger. The final common pathway before the motor pathway is the hypothalamus along with the amygdala and the motor cortex. Theres a negative feedback loop to inhibit these pathways. Lesions in different parts of the hypothalamus can cause different things like starvation or excessive hunting. The set point can change very easily through plasticity. We could upregulate the feeding pathway, downregulate the negative feedback loop. Stimulating (cid:271)eha(cid:448)io(cid:396) does(cid:374)"t satiate (cid:271)e(cid:272)ause (cid:449)e a(cid:396)e (cid:271)ypassi(cid:374)g pa(cid:396)t of the (cid:373)e(cid:272)ha(cid:374)is(cid:373), the sti(cid:373)ulati(cid:374)g (cid:373)e(cid:272)ha(cid:374)is(cid:373) saying we are hungry is being bypassed. Eating a french fry is an unconditioned stimulis. The dopamine pathway is unconditioned, its unlearned, it just happens. Opiods acting on he nacc have a more potent effect than the vta. Then the consequence feeds back to the behavior.
