HMB200H1 Lecture Notes - Lecture 10: White Matter, Asperger Syndrome, Snp Array
Document Summary
It is hard to place autism on a threshold bc many factors come into play (at what point is it a disorder) Research domain criteria (rdoc: dsm diagnosis is based on observations and symptom reports, research domain criteria (rdoc): is based on idea that looking at biological factors is important. Intended as a framework to guide classification and use biology for specific treatments. Phenotypes of asd: higher density in white matter tracts (larger brains, reduced minicolumn width in autism leading to less dendric arborization (branching) and column organization. Repetitive behaviours: pfc substania nigra (basal ganglia structure that plays an key role in reward and movement) striatum (also basal ganglia structure part of the motor and reward systems) behaviour. Case study r451c mouse model: neurexins: presynaptic cell adhesion molecules (cam) binding neuroligins, neuroligins: cell adhesion protein on the postsynaptic membrane that mediates the formation and maintenance of synapses between neurons.
