HMB200H1 Lecture Notes - Lecture 5: Neural Cell Adhesion Molecule, Cell Adhesion Molecule, Evoked Potential
Document Summary
Neurons receive both excitatory and inhibitory inputs. Neurotransmitters bind to receptors to activate them. Exogenous compounds can also bind to the receptors. Receptor blocker/activator can inhibit/activate post synaptic neuron. Blocking depolarization = less excitation, not inhibition. Blocking hyperpolarization = less inhibition, not excitation but will result in more excitation. If agonist binds to same site = depolarization. If antagonist binds to same site = block action potential, no change/can induce hyperpolarization. Inputs from far away sites arriving at same time. Inputs from close sites happen at same time. Glutamate and gaba/glycine are major excitatory/inhibitory signaling systems in the brain. Tms can produce weak electric currents and stimulate neurons. Activation of muscles from stimulation of motor regions. F-actin assembly required for spine and synapse formation. Cell adhesion molecules and extracellular matrix (ecm) Ecm poly molecules and neural cell adhesion molecules (ncams): stability of synaptic connections. Flexibility of synapses (less developed ecms and more flexible ncams.
