HMB265H1 Lecture Notes - Lecture 4: Inbreeding Depression, Product Rule, Mutual Exclusivity

• School: UTSG
• Department: Human Biology
• Course: HMB265H1
• Professor: Maria Papaconstantinou

Document Summary

Hmb265: lecture 4 - mendelian traits in humans & human pedigree analysis (sept. 19) Mendel"s law apply to pea plants but also apply to humans. Individuals w/ 1 dominant (wild-type) allele can synthesize enzyme called. Enzyme converts amino enzyme into dark pigment (melanin) that occurs in skin, hair, eyes. Individuals w/ 2 wt/dominant alleles produce functional tyrosinase enzyme and get pigmented phenotype (homozygotes w/ 2 dominant alleles) phenotype. Heterozygote = sufficient to produce enough enzyme to get pigmented. No tyrosinase produced, melanin not produced = albino phenotype. Also diseases caused by recessive vs dominant alleles. Homozygous dominant and heterozygotes show affected phenotype. Parents: cross 2 individuals that are heterozygous: cc x cc. Have 1 copy of dominant c allele (curly hair phenotype) Can have child that has straight hair b/c 2 copies of recessive allele. W/ autosomal recessive trait, only individuals w/ w copies of recessive allele exhibit. May skip generations (unlike dominant traits) affected phenotype.