HMB265H1 Lecture Notes - Lecture 1: Dihybrid Cross, Mendelian Inheritance, Silent Mutation
15 Jul 2018
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HMB265H1 Full Course Notes
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Medical genetics = identify genetic cause of disease to cure, diagnose & prevent disease, gene therapy (crispr), pharmacogenomics/how genes affect your response to drug treatment. Agricultural genetics = use of gmos as food source. Conservational genetics = use genetics to restore biodiversity. Conditions are not always purely genetic also have environmental factors. Pre-mendelian: used breeding w/ livestock, had some understanding that traits are passed in families. Mendel: looked at traits individually, not at whole organism, good model organism, fast growth, short generation, selfing (cut anthers & transfer pollen), many offspring, performed controlled experiments. Discrete/simple inheritance: either/or trait antagonistic pairs: mutually exclusive traits (discrete, either/or) Continuous/complex inheritance: seems to blend, though not the case. Reciprocal cross: traits coming from opposite parent, mendel used this to disprove uniparental inheritance. Monohybrid cross: aa x aa reappearance of recessive trait disproves blending, disproves uniparental inheritance: p f1 f2, dominant/recessive law of segregation. Dihybrid cross: aabb x aabb law of independent assortment.
