HMB265H1 Lecture Notes - Lecture 19: Non-Coding Rna, Dna Methyltransferase, Epigenome

• School: UTSG
• Department: Human Biology
• Course: HMB265H1
• Professor: Naomi Levy-Strumpf, Stephen Wright

Document Summary

Epigenetics (epigenome) heritable modifications in gene function not due to changes in the base sequence of dna. Can be inherited in the f2 and subsequent generations as well. ** before, our underlying assumption was that genotype = phenotype (with some contribution from the environment as well) ** Igfr2 (paternally imprinted) the receptor for igf2. Air (ncrna) antisense transcript that suppresses expression of igfr2: maternally, cpg islands controlling air transcription is methylated (ie. silenced) and igfr2 is expressed. ** overall leads to changes in gene expression ** Agouti, under normal developmental control, results in the brown coat colour. The avy allele has a has a murine intracisternal a particle (iap) upstream; small. Unmethylation of the iap (retrotransposon insertion) results in the activation of a cryptic promoter site (leads to constitutive and ectopic agouti expression, leading to a yellow coat colour also diabetes, obesity and tumour formation)