HMB265H1 Lecture 1: HMB265H1F Course Syllabus-Fall 2015
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Welcome to HMB265H1F General and Human Genetics
Course Syllabus 2015-2016 Fall Session
Course Coordinator: Dr. Jen O’Leary, Human Biology Program
Course Instructors: Dr. Stephen Wright, Ecology & Evolutionary Biology (Lectures 1-11)
Dr. Belinda Chang, Ecology & Evolutionary Biology and Cell & Systems
Biology (Lectures 12-22)
Lectures: Tuesdays 3:10 to 5:00 pm* and Fridays 1:10 to 2:00 pm, Convocation Hall
*Lecture Review Session/Office Hours: Tuesdays 4:10 to 5:00 pm, Convocation Hall
*Midterm Exam—Tuesday, October 27th from 3:10 to 4:20 pm
Arts & Science Calendar Course Overview [24L, 12T]: An introduction to classical and modern
methods of genetic analysis. Topics include Mendelian genetics, the genetics of human population
and disease, genomics, and applications of genetics to human society.
Co-requisite: (BIO230H1)/ BIO255Y1/(BIO240H1+BIO241H1)
Exclusion: BIO260H1, BIO207H5
Course Description: An understanding of genetics is essential for all life science students, and is
becoming increasingly important for all members of society. This course is designed to give you a
solid grounding in genetics. Topics include Mendelian genetics, the genetics of human population
and disease, genomics, and applications of genetics to human society. A variety of activities—
lectures, readings, mandatory tutorial quizzes, and assignments—are planned to help you learn the
material. To do well in the course, we recommend that you participate fully in all of these activities
and that you keep up to date with the material. We hope you enjoy the course.
Lecture notes will be posted under Course Documents before the lecture, please bring a printed
copy to class. Make sure you have a copy of the lecture notes in your possession well before
quizzes, the midterm test and the exam in the event of a problem accessing the course website.
If you have questions regarding the course material, please post them on the Discussion Board
section of the course website. We encourage students to answer questions too—this is a great way
to make sure you understand the material.
For questions of an administrative nature unrelated to course content, please post on the Discussion
Board section of the course website under “administrative questions”, or contact Dr. Jen O’Leary
via the course administrative email: firstname.lastname@example.org.
Required textbook and solutions manual (available as a bundled package, U of T bookstore):
1. Hartwell LH, Hood L, Goldberg ML, Reynolds AE, Silver LM, Karagiannis J and
Papaconstantinou M (2014) Genetics: From Genes to Genomes, 1st Canadian edition, McGraw-Hill
2. Karagiannis J and Papaconstantinou M (2014) Solutions Manual for Genetics: From Genes to
Genomes, 1st Canadian edition. McGraw-Hill Ryerson, Canada.
Only pages 1-2 are available for preview. Some parts have been intentionally blurred.
Optional Online Assignments for Practice:
3. Connect® for Genetics: From Genes to Genomes, 1st Canadian edition, is a digital teaching
and learning environment that integrates an interactive eBook, animations, and communication
tools, as well as practice quizzes, tests, and assignments. After purchasing a package from the U of
T bookstore with the Connect® Access Card, please follow the instructions posted under Syllabus
on the Blackboard course site to register your code.
4. Online Assignment Modules will also be available for practice on Connect. These are
interactive online modules that will be used to enhance the lecture material with the ultimate goal
of improving student learning outcomes.
HMB265 Lecture Schedule:
The genetics & genomics of human biology
Mendelian genetics for single gene traits
Molecular basis of genetic polymorphisms and their
2, 7, 8, 14,
Extensions of Mendelian genetics I – dominance, co-
dominance, penetrance, expressivity
Extensions of Mendelian genetics II –
Sex-linked traits & chromosomal theory of inheritance
Linkage & recombination
Quantitative trait loci
Genetic mapping & complex traits
November break-no classes
No classes due to Fall Convocation
Large-scale chromosomal changes I
Large-scale chromosomal changes II
Using genetics to understand development
Genetics of cancer
*Required pages will be posted in the lecture notes.
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