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Lecture 1

HMB265H1 Lecture 1: HMB265H1F Course Syllabus-Fall 2015


Department
Human Biology
Course Code
HMB265H1
Professor
Stephen Wright
Lecture
1

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Welcome to HMB265H1F General and Human Genetics
Course Syllabus 2015-2016 Fall Session
Course Coordinator: Dr. Jen O’Leary, Human Biology Program
Course Instructors: Dr. Stephen Wright, Ecology & Evolutionary Biology (Lectures 1-11)
Dr. Belinda Chang, Ecology & Evolutionary Biology and Cell & Systems
Biology (Lectures 12-22)
Lectures: Tuesdays 3:10 to 5:00 pm* and Fridays 1:10 to 2:00 pm, Convocation Hall
*Lecture Review Session/Office Hours: Tuesdays 4:10 to 5:00 pm, Convocation Hall
*Midterm ExamTuesday, October 27th from 3:10 to 4:20 pm
Arts & Science Calendar Course Overview [24L, 12T]: An introduction to classical and modern
methods of genetic analysis. Topics include Mendelian genetics, the genetics of human population
and disease, genomics, and applications of genetics to human society.
Prerequisite: (BIO120H1+BIO130H1)
Co-requisite: (BIO230H1)/ BIO255Y1/(BIO240H1+BIO241H1)
Exclusion: BIO260H1, BIO207H5
DR=SCI; BR=4
Course Description: An understanding of genetics is essential for all life science students, and is
becoming increasingly important for all members of society. This course is designed to give you a
solid grounding in genetics. Topics include Mendelian genetics, the genetics of human population
and disease, genomics, and applications of genetics to human society. A variety of activities
lectures, readings, mandatory tutorial quizzes, and assignmentsare planned to help you learn the
material. To do well in the course, we recommend that you participate fully in all of these activities
and that you keep up to date with the material. We hope you enjoy the course.
Lecture notes will be posted under Course Documents before the lecture, please bring a printed
copy to class. Make sure you have a copy of the lecture notes in your possession well before
quizzes, the midterm test and the exam in the event of a problem accessing the course website.
If you have questions regarding the course material, please post them on the Discussion Board
section of the course website. We encourage students to answer questions toothis is a great way
to make sure you understand the material.
For questions of an administrative nature unrelated to course content, please post on the Discussion
Board section of the course website under “administrative questions, or contact Dr. Jen O’Leary
via the course administrative email: hmb265h.hmb@utoronto.ca.
Required textbook and solutions manual (available as a bundled package, U of T bookstore):
1. Hartwell LH, Hood L, Goldberg ML, Reynolds AE, Silver LM, Karagiannis J and
Papaconstantinou M (2014) Genetics: From Genes to Genomes, 1st Canadian edition, McGraw-Hill
Ryerson, Canada.
2. Karagiannis J and Papaconstantinou M (2014) Solutions Manual for Genetics: From Genes to
Genomes, 1st Canadian edition. McGraw-Hill Ryerson, Canada.

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Optional Online Assignments for Practice:
3. Connect® for Genetics: From Genes to Genomes, 1st Canadian edition, is a digital teaching
and learning environment that integrates an interactive eBook, animations, and communication
tools, as well as practice quizzes, tests, and assignments. After purchasing a package from the U of
T bookstore with the Connect® Access Card, please follow the instructions posted under Syllabus
on the Blackboard course site to register your code.
4. Online Assignment Modules will also be available for practice on Connect. These are
interactive online modules that will be used to enhance the lecture material with the ultimate goal
of improving student learning outcomes.
HMB265 Lecture Schedule:
Date
Lecture
Number
Topic
Textbook
Chapter*
Sep 15
1
The genetics & genomics of human biology
1
Forward Genetics
Sep 18
2
Mendelian genetics for single gene traits
2
Sep 22
3
Molecular basis of genetic polymorphisms and their
Detection
2, 7, 8, 14,
15
Sep 25
4
Pedigree analysis
2
Sep 29
5
Extensions of Mendelian genetics I dominance, co-
dominance, penetrance, expressivity
2
Oct 2
6
Extensions of Mendelian genetics II
complementation/allelism, epistasis
2, 8
Oct 6
7
Sex-linked traits & chromosomal theory of inheritance
3
Oct 9
8
Linkage & recombination
4
Oct 13
9
Linkage mapping
4
Oct 16
10
Population genetics
12
Oct 20
11
Genomics
19
Oct 23
12
Quantitative genetics
2, 7
Oct 27
MIDTERM EXAM
Oct 30
13
Quantitative trait loci
12
Nov 3
14
Genetic mapping & complex traits
15, 20
Nov 6
15
Mutation
7, 8
Reverse Genetics
Nov 10
November break-no classes
Nov 13
No classes due to Fall Convocation
Nov 17
16
Transposable elements
8, 9
Nov 20
17
Large-scale chromosomal changes I
9
Nov 24
18
Large-scale chromosomal changes II
9
Nov 27
19
Epigenetics
6, 11
Dec 1
20
Using genetics to understand development
17
Dec 4
21
Genetics of cancer
16
Dec 8
22
Gene therapy
2, 19
*Required pages will be posted in the lecture notes.
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