HMB265H1 Lecture : Notes taken in class

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redtermite204

5 Apr 2011

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20-25% based on first semester material; rest based on second semester material. register on rosi; email sent to you to provide more info on filling out priority ranking forms: to match you to courses you really want. results from mutations in different types of genes: ie. in proto-oncogenes. cells grow out of control, destroying healthy tissue. Failure in mechanisms controlling cell growth, proliferation, and death: result from dna damage from mutations, or types of altered gene expression. normal cell makes decision whether or not to divide based on signals received from neightbouring cells: positive or stimulatory signals to divide, negative signals so stop dividing. cancer cells either insensitive to negative signals or produce own stimulatory signals: autocrine stimulation. normal cells when proliferate, when come in contact with normal cells, stop dividing: one cell layer only if plate normal cells. contact inhibition: tumour cells different don"t receive or listen to signals from neighbouring cells.

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For your responses please justify your answer. No justificationfor answer will recieve "needs work" rating.

Multiple choice. Circle all that apply.
49. Which of the following statements concerning cancer cells arecorrect?
A) The ability of cancer cells to cross the basal lamina is arelatively unimportant factor in
determining whether they will metastasize to form secondarytumors.
B) Cancer cells gradually accumulate a variety of mutations thatcause them to progressively
become less responsive to the external signals that normallycontrol cell growth.
C) Over half of human tumor cells exhibit mutations in the p53gene.
D) The proliferation of cancer cells is sensitive to compounds thatblock microtubule
depolymerization.
E) Cancer cells generally retain normal cell cycle checkpointfunctions.

True or False. For either response, please justify youranswer.

50. True/False One possible function of a tumor suppressor geneis to control a cell cycle
checkpoint.

Which of the following describes differences between normal cells and cancer cells?

Normal cells have multiple nucleoli, while cancer cells have a single nucleolus.

A	Normal cells have coarse chromatin, while cancer cells have fine chromatin.

B	Normal cells have multiple nuclei, while cancer cells have a single nucleus.

C	Normal cells have a large amount of cytoplasm, while cancer cells have a small amount of cytoplasm.

D	Cancer cells exhibit controlled cell division, while normal cells exhibit uncontrolled cell division.

1. What specific mutation occurs in oncogenic Ras and how does that affect function? Why does this mutation show up in cancer and not some other types of mutations? Is it because mutated Ras cells grow uncontrollably and invade death signals. Please help.

Also, how is Ras different from Myc?

HMB265H1 Lecture : Notes taken in class

HMB265H1 Full Course Notes

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