HMB300H1 Lecture 15: When Memories Disappear – Alzheimer’s Disease.pdf
Document Summary
Ad is becoming more common. Lecture 15: when memories disappear alzheimer"s disease. Between 2000 and 2008, there has been a 66% increase in the incidence of ad. Up because increase in incidence, no effective therapy, or better diagnosis. Difficulty with planning and solving problems. Confusion and spatial disorientation. Decreased or poor judgement cholinergic fibers, areas of pfc, poor judgment or decision making. Changes in mood and personality. Problems with communication and difficulty finding words: most pathology begins in medial temporal lobe, Predisposing yourself to developing, and subclinical feature of neurodegeneration, lack of ability to control sleep. Gfap, marker for glial also a marker for adult stem cells. Immune response (microglial infiltration) often microglial response, the immune cells in the brain. Balance between alpha and beta secretase, mutation in app, drive to beta secretase pathway. A peptide formed in higher concentrations. Increases likelihood that you will generate toxic forms of the a . Apolipoprotein e: apoe3 is best here.
