HMB300H1 Lecture Notes - Lecture 8: Substantia Nigra, Dopaminergic Cell Groups, Dopaminergic Pathways
Document Summary
Hmb300: dopamine and its downstream effects (lecture 8) The current model for most neurodegenerative conditions is that neurons die via apoptosis or a programmed form of cell death. This has very important clinical implications as turning on or turning off specific genes/proteins is a method to stop or possibly reverse neurodegeneration. Neurodegenerative diseases such as pd, ad, als, and possibly hd all implicated to be apoptotic pathway. Best neurodegenerative disease to look at as pd! Other pigmented neurons can also be affected however, like the locus coeruleus, substantia innominata, etc. Continuous and progressive disease symptoms worsen with time (no recovery) Etiology (known causes that are secondary): Side effects of several antipsychotic drugs (i. e. phenothiazides, butyrophenones, reserpine by reducing catecholamines [da]) Pesticides, herbicides, industrial chemicals what-ever this chemical does (in farming areas or near large cities) might be working on the mitochondria that inhibit complex 1.
