HMB450H1 Lecture Notes - Lecture 1: Blastula, Neural Plate, Subventricular Zone

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19 Sep 2018
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Embryogenesis: gastrulation (week 3: gastrulation is when the primitive streak is set up which causes 2 major events, loss of overall symmetry with anterior-posterior (up-down) and proximal-distal (left-right, initiation of the three-germ layer formation; Endoderm: epithelium, organs associated with digestion and respiration. Ectoderm: nervous system, epidermis: mesoderm: muscles, cartilage, dermis, vasculature, bone, and connective tissue. Differentiation: regional differentiation occurs through morphogens these signaling molecules will diffuse to form various conc. Gradients and thus differentially effect cell development: different concentrations of morphogens repress or activate different transcription factors, cells respond to this conc. Thresholds or secreted factors by expressing different transcription factors (e. g. there is a high amount of wnt in the spinal cord, but low conc. Of wnt in cells that will form the cortex) Signaling molecules: there are 3 critical morphogens/signalling molecules, shh, bone morphogenic protein (bmp): specifies dorsal neurons (i. e. sensory interneurons, wnts: specifies caudal neurons (brainstem/spinal cord)

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