HMB471H1 Lecture Notes - Lecture 4: Modafinil, Anisomycin, Grin2B
Document Summary
Stimulants amphetamines commonly used for: soldiers and fighter pilots (for courage and to stay awake) Benzadrine, methylphenidate (similar to adderall), used widely to be more productive: students, professionals etc. Modern more targeted versions act more specifically on sleep/wake pathways (eg. treatments for narcolepsy) Modafinil (provigil, alertec): elevates levels of neurotransmitters including serotonin, histamine, norepinephrine, Sleep deprived conditions kept individuals up for a long period of time. Change in enjoyment of doing things, and also change in confidence (overconfidence when you"re on stimulants) The challenges of testing stimulants. Can feel the stimulant (heart rate, etc. Cannot feel the mind) Objective and subjective cognitive enhancing effects of mixed amphetamine salts in healthy people. Stages of learning and memory: 4. statistical power, sample size chosen for sufficient power to observe moderate effect. Here too we generally failed to support these hypotheses, although a minority of specific statistical tests showed the predicted patterns. Below median baseline performers did slightly better.
