HMB200H1 Lecture Notes - Lecture 13: Leptin Receptor, Blood Sugar, Leptin

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18 Apr 2014
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Lecture 13: feeding and obesity. Invest in a huge amount of resources to maintain this. If there is low blood glucose, ketones are used as an energy source for the brain. Special access to glucose - gets it even when other body parts are starving. Fainting helps brain get these when blood pressure drops. Hypothalamus and feeding: lh and pvn lesions less eating, vmh and arcuate lesion more eating. Critical areas/feeding centers: lateral hypothalamus (lh), paraventriclar nucleus (pvn) and ventromedial hypothalamus (vmh) Leptin is peptide produced in fat cells in proportion to size: db/db mice have mutation in leptin receptor gene. Leptin receptors in arcuate n. and lh. Seritonin agonists seem to work for humans; large peptides do not because it cannot cross the blood brain barrier. Feelings of depression and resolved by intense feeding. Long term fat storage and long term energy is influenced by leptin signal. Critical areas are just above the pituitary.

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