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Lecture 10

Lecture 10 - Circadian Rhythms

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Human Biology
John Yeomans

HMB200H1S L10 Feb 08 2012Continuously moving paper certain segment Circadian Rhythmslength for one dayBiology how animals reproducesurviveSome variability more than hamster but mostly Avoid predators reproduce when to find foodconsistent dailyEcological nicheCut up paperssee what time of day most activeCircaaboutUse daynight lightdarkCircadianabout 24hrsCircadian organizationEndogenous rhythm when in light or dark but not Bhvr organization all animalsexactly 24hrsHow hypothal coordinatesregulates bhvrConstant lightwaking up later every dayVery small structure in brain yet large effectEndogenous rhythm changing moving to right Critical genestheir evolutionso about 245hrs every daySmallof critical genesImplies internal clock is changing freerunningShared among mice flies humansAlso true of flies almost all animalsExpression in hypothalbody of dif animalsWhen constant conditions existCorrelations in plants flies humansshows Very stable in most animalsvery important since conserved24s hrs when light to dark every 24hrsEvolution of retinavisionStrongly controlled by direct projection from Activity RhythmsretinaEndogenous clock Measured in constant conditions Specialized prot not rhodopsinstill 2325 hr free runningChanged understanding of how retina uses Rhythm is lost when SCN lesioned in mammals or opsins how opsins
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