HMB473H1 Lecture Notes - Lecture 9: Dentate Gyrus, Plasmin, Euchromatin
Document Summary
Finding new neurons using cell markers: adult neurogenesis is the process of generating new neurons which integrate into existing circuits after fetal and early postnatal development has ceased only appears to occur in subventricular zone (svc): dentate gyrus, and olfactory epithelium, migrates into the cortex, even in humans, dentate gyrus (hippocampus) granule cell layer (cell bodies), easy to study, brdu any new cells. Potential functions include: (fns of hippocampus: (fine) spatial memory, context discrimination, flexible use of memory, long term memory, antidepressant response, addiction since younger neurons very plastic: 40% of neurons turned over are new: 20% of cells in your dentate gyrus are new when adult, as you age you lose neurons as well, will plateau, c: neurogenesis decreases rapidly as rats age, only small %age of turned over cells at old age, less than 1000 cells are new, (injected brdu)
