LMP299Y1 Lecture 1: Lmp notes.docx

• School: UTSG
• Department: Laboratory Medicine and Pathobiology
• Course: LMP299Y1
• Professor: all

Document Summary

Biology: normal response of cell to the env. Pathology: abnormal response of cell to env or normal response of cell to abnormal env. Pathobiology: a cells response (in the context of organ and individual) to changes in the env (env is exogenous or endogenous) Central theme: change in env->adaptive response->cell death, cell injury and disease. Malignant tumour (cancer) (sarcoma, carcinoma): expansion and invasion [if shortage of blood supply=cell death, necrosis] and metastasis. Classification of cancers: simple: one neoplastic cell type. Mesenchymal in origin (sarcoma: ct tissue and derivatives. Lipoma, liposarcoma (adipose tissue: chondroma, chondrosarcoma (cartilage, osteoma, osteosarcoma (bone, endothelial tissue, hemangioma, hemangiosarcoma (bv, mesothelioma, mesotheliosarcoma (mesothelium) Lymphangioma, lymphangiosarcoma (lv: lymph tissiue and bone marrow. Leiomyoma, leiomyosarcoma (smc) -uterus: rhabdomyoma, rhabdomyosarcoma (striated) eyelid. Epithelial in origin: epithelium, papilloma/adenoma (glandular), carcinoma, placental epithelium, hydatid mole, choriocarcinoma, testes, seminoma, embryonal carcinoma, mixed: multiple neoplastic cell types but from one germ layer, salivary gland, kidney.