NFS284H1 Lecture Notes - Lecture 17: Atrophic Gastritis, Autoimmune Disease, Homocysteine
7 Apr 2018
School
Department
Course
Professor
Document Summary
Vitamin functions: which are required for energy metabolism, thiamine, riboflavin, niacin, pantothenic acid, biotin, what are antioxidants, vitamin c, vitamin e, what are required for single carbon metabolism (transfer of methyl groups), vitamin b6, folate, vitamin b12. Does b6 require folate and b12: no. What is b6 involved in: transamination, deamination, atp and glucose production, decarboxylation, neurotransmitters synthesis. Increasing b6, b12, folate reduces homocysteine levels which lowers risk of cvd. What is the main rxn: methyl folate + b12 -> folate + methyl b12. How does this reaction reduce homocysteine: methyl group from methyl b12 gets transferred to homocysteine which converts it to methionine. What can b6 also do: convert homocysteine to cysteine. Is there an association between folate intake and lower cvd risk: yes, stroke but not heart attacks. Is there a causal link between from folate intake and lower cvd risk: no. What is the naturally occurring folate: folate polyglutamate.
