NFS284H1 Lecture Notes - Lecture 6: Statistical Significance, Mediterranean Diet, Cohort Study
9 Nov 2016
School
Department
Course
Professor
Document Summary
Shows causation, casual links between intervention and outcome. Evidence from intervention trails are considered stronger than observational studies. Usually measures risk factors of disease rather tha(cid:374) (cid:862)hard(cid:863) disease outco(cid:373)es. Difficult to sustain especially if you are making substantial changes to diet. Shows associations, but not casual links and outcomes; vulnerable to confounding. Nutrition research science applied: fro(cid:373) (cid:862) e(cid:448)e(cid:374) cou(cid:374)tries(cid:863) to the mediterra(cid:374)ea(cid:374) diet. Hypothesis lifestyle factors affects the risks of disease. The study was observational and included 12763 healthy men, aged 4-59; from seven different countries- 16 cohorts. Dietary intake was evaluated at start of the study. Duration: health information obtained from participants for 5-10 years and continuing follow-up- up to 40 years. Results: positive association between serum cholesterol and cardiovascular disease. Positive association between saturated fat and cardiovascular disease. Positive association between saturated fat and serum cholesterol. Limitations to the study: did not have dietary database detailed intake of 20-50 men in each cohort (1000-2000)
