NFS284H1 Lecture Notes - Lecture 14: Vitamin B6, Folate Deficiency, Homocysteine
13 Mar 2018
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Vitamin b6, vitamin b12, folate, and homocysteine hypothesis: homocysteine is toxic to blood vessels and high levels of homocysteine increase risk of cardiovascular disease. Increasing intake of b6, b12, and folate reduces risk of cardiovascular disease. Folic acid: used in fortified food, more stable than folate. Function in the body: single carbon metabolism. Synthesis of the components of dna: dna methylation. Folate deficiency results in magaloblastic or macrocytic anemia: adequate amounts of folate- dna synthesis- important in red blood cell formation- red blood cell precursor divides properly. Folate deficient- cells unable to divide- abnormal cells- don"t function properly. Folate intake in canada: too little or too much: human observational studies. Increased folate intake associated with decreased colon cancer risk: animal studies. Increased folate in the absence of pre-existing cancer-->decreased cancer risk. Increased folate in the presence of pre-existing cancer-->increased cancer risk. Lack of vitamin b12-->secondary folate deficiency (need b12 to metabolize folate indirectly)--
