NFS284H1 Lecture 7: NFS284H1 – Chapter 7
Document Summary
As the bmi increases so does the mortality rate. Figure 7. 13 excess body fat and disease risk among canadians. As we go from overweight to extremely obese, relative risk for blood pressure, diabetes, and heart disease increases. Disease characterized by a series of genetic mutations that result in a cell that: De differentiates (no longer functions as intended) Becomes proliferative (grows uncontrollably: does not respond to stop signals) Becomes resistant to programmed cell death (apoptosis) Normal colon epithelium single mutated cell single tumour large tumour malignancy. Method the body uses to get rid of damaged cells it cannot repair. Growth factors that promote cell growth: insulin. In postmenopausal women, stimulates the growth of breast tumours. Bound to sex hormone binding globulin (shbg_ Less bioavailable (less stimulation of cell growth) More bioavailable (more stimulation of cell growth) Purpose: to determine if there is an association between bmi and colon cancer risk. Men had a higher rr increase when bmi increased.
