NFS382H1 Lecture 9: Lecture 9 Cancer Prevention or Exacerbation

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Lecture 9 cancer prevention or exacerbation folate and vitamin d. Evidence based medicine aims to: apply best available evidence from clinical trials to clinical decision making, assess strength of evidence with respect to risk/benefits of treatment/diagnostic tests. Phase 3: final testing: efficacy and compare to current rx. Clinical evidence against smoking based on prospective cohort epidemiology. Immunomodulation of 1,25(oh)2d: geographical variation, season of birth, vddr1 and concurrent ms case study, relapse/remission and increase/decrease 25(oh)d, oral vitamin d intake, uvb radiation, decreased 25(oh)d, seasonal mri activity. A phase 1/2 dose escalation study of high dose of vitamin d supplementation in ms patients (randomized, open-label, matched intervention trial) Summary: mean serum 25(oh)d concentration ~420nmol/l without significant changes in serum/urinary ca measures, dosing regimen physiologically attainable 25(oh)d concentrations at 1yr, no significant adverse effects, treatment group improve. Lymphocyte proliferation assay: t cell proliferative response to ms-associated antigentic stimulation were significantly reduced in treated, no change in markers of immune cell signaling/trafficking.

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