PCL102H1 Lecture Notes - National Institutes Of Health, Mendelian Inheritance, National Institute Of Neurological Disorders And Stroke
Document Summary
During seizure activity, 90% of the cells in any part of the brain are firing, and they"re all firing together. If you ask what transmitters are elevated during seizure discharge, the answer is: all of them. The hemisphere where partial seizures occur is often hypometabolic (decreased activity) in between seizures. This suggests that maybe the brain is trying to stop seizure activity by an excess of inhibitory control on the side with seizure focus. Focus of seizure is old term for epileptogenic zone: seizure activity may kill neurons this is certainly true if the seizure activity is extended into status epilepticus. Many types of status (absence, complex-partial, tonic-clonic which is the most dangerous and needs to be treated at a hospital if longer than 5 minutes) Seizures often arise in the temporal lobe (which is the most common place in the brain where they arise).
