PCL102H1 Lecture Notes - Frontal Lobe, Basal Ganglia, Agonist
Document Summary
Physical: lobotomy (outdated, ect (outdated, recall forced-normalization it was the motivation for ect. Talking: analysis, cognitive behavior therapy (adjunct; not in isolation) Drugs: derived from antihistamines (that target the h1 receptor: first called major tranquilizers , then called neuroleptics , now called anti-psychotics . Also: anti-emetic [vomiting/nausea area postrema/chemo trigger zone [ctz] is very sensitive to dopamine agonists they make you throw up antagonists are anti-emetic)], anesthesia and other psychotic disorders (i. e. , alzeimers patients presenting with psychotic symptoms) Yes, 95% improvement in acutely ill (positive symptoms: seeman: help positive symptoms: 95% (carlson: only 65%) Normal enough to live at home and work. Don"t like the drugs and many go off them - need family support. Slight change = thioxanthines: e. g. thiothixene. Antipsychotic effects + motor side effects + sedation + hypotension: these early drugs bound to many receptors (dirty drugs) : chlorpromazine, fluphenazine, fluphenazine decanoate: fluphenzine decanoate is fluphenazine modified to have a high partition coefficient.
