PCL102H1 Lecture Notes - Insomnia, Catecholamine, Reward System
Document Summary
But it"s all over the map and changes significantly in the 11th edition. An ongoing problem with the field, partly because there isn"t a good animal model. Physiology: what"s known, a model based on physiology. Neurochemistry: what"s known, the classic del gado experiment. This has long been one of the problems in the field: if you. Don"t know where to look, it"s hard to find the. This is different from schizophrenia where cell loss is the cause. Effects of bipolar episodes: ventricles enlarge (not cause!) Effects of depression: hpc smaller (a reliable finding: possible explanation: stress inhibits neurogenesis. This particularly occurs in the hpc in the fascia dentate in the sub-granular zone (area of hilus [stratrum polymorph] that immediately borders stratum granulare). Not very specific: cell loss all over the place. Abnormalities reported in pfc, bg, hpc, thalamus, cerebellum, temporal lobes (all grey matter/cell bodies) - also less white matter.
