PSL300H1 Lecture Notes - Lecture 7: Gluconeogenesis, Endorphins, Acne Vulgaris
Document Summary
Adrenla medulla = modified sympathetic ganglia: secretes catecholamines (e. g. epinephrine) Adrenal cortex = steroid factory: secretes, sex steroids eg testosterone, mineralocorticoids eg aldosterone, glucocorticoids eg cortisol. Intestinal blood vessels: a- receptors only leads to vasoconstiction. Local vasodilation caused by metabolites (co2 etc: beta- 2 receptor response. Metabolite accumulation in these vessels during muscle contraction causes vasodilation. Regulation of dhea and adrostenedione synthesis: stimulated by adrenocorticotrophic hormone (acth) - activates an enzyme at an early step in steriodogenesis, but intrinsic changes in enzyme activity occur during the lifespan, eg. This is the key that regulates (the enzyme 11b: when 11b not present, cell is non responsive to aldosterone. Inhibit inflammatory responses o: some specific uses: poison ivy, allergies, asthma, long term use can result in inhibition of acth secretion and atrophy of cortisol secreting cells. Pattern of cortisol secretion: diurnal, secreted at night (early hours of morning, at lowest around 1 am and highest around noon.
