PSL350H1 Lecture 8: Lecture 8- How can we assess general protein translation_.pdf
Document Summary
Life cycle of a protein. Geometric sequencing protein level. About 10 years since human genome is sequenced. There are some species with very small genome or very large genome. Genetic information makes a protein. Complexity relates to the folding of protein, post- translational modifications: suspected to have 1 million protein products. Through splicing, phosphorylation, other post- translational modifications, glycosylation, ubiquination Then the protein can be degraded. Proteome - every protein that can be detected in the sample. It changes during growth, diseases, drug use The proteome is dependent on environmental factors, disease, drugs, stress, growth conditions. Protein level in a cell at a given time is dependent on: Efficiency of translation in the cell. The rate of degradation of the protein. This is a 4- exon gene: can modify it many ways, will generate many different proteins. Transcriptome - measure on the rna level: can measure on a large scale of rna.
