PSL350H1 Lecture 4: PSL350 Lecture 4
15 Mar 2016
School
Department
Course
Professor
Document Summary
Epi" above (genetics: historically, heritable changes in gene expression that do not involve changes to the dna sequence, now, epigenetics also encompasses the events that alter gene expression that are not transcriptional regulation. Epigenetics mechanism (proposed) similar to transcription factors. Writers: add or modify the target molecule. There is only weak evidence, there are things that modify/erase the residue yes, and can bind as a reader, but there is a major flaw. Dna target is cytosine for methylation (addition of ch3), and or hydroxylation. Mrna (maybe) micrornas can bind to it to inhibit or modify. Ubiquin (ub) monoubiquitin can be a signal in the nucleus for the histone signals to be expressed or not. A transcription factor (foxa2: recognizes a dna sequence, localizes to a coordinate in the genome, transcription factors are specific and can occur throughout the genome, and selected for a specific location. Hdac2 to a histone peptide recognizes a t t it fi d di t h.
