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Lecture

PSL201Y1 Lecture Notes - Basal Ganglia, Occipital Lobe, White Matter


Department
Physiology
Course Code
PSL201Y1
Professor
Yue Li

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9 THE NERVOUS SYSTEM: CENTRAL NERVOUS SYSTEM
General Anatomy of the Central Nervous System
GLIAL CELLS
75-90% of the CNS is composed of glial cells (neuroglia) that provide support to neurons.
5 types: Schwann cells, oligodendrocytes, microglia, ependymal cells, and astrocytes.
All glial cells release growth factors involved in the development of the nervous system.
ASTROCYTES
o Star-like appearance, most diverse.
o Are necessary for the normal development of the nervous system as well as its
continued support throughout life.
o Direct development of special capillaries that restrict the movement of certain molecules
between the blood and the CNS (blood-brain barrier).
o They guide developing neurons to their correct destination and regulate the
development and maintenance of synapses. Support the regeneration of damaged axons.
o Critical for the maintenance of normal extracellular environment surrounding neurons,
especially at synapses (i.e. maintaining extracellular K levels for neuron excitability).
o Help remove biogenic amines and glutamate from the synaptic cleft (excess glutamate is
toxic); protect neurons from oxidative stress and remove cellular debris.
o They synthesize glutamine, which is then released into the interstitial fluid and picked
up by other neurons to form glutamate (excitatory neurotransmitter).
o Stores glycogen (used to make lactate for neurons as a source of energy).
o They regulate synaptic communication between neurons, and have the ability to directly
communicate with neurons and other glial cells (i.e. other astrocytes).
o They can function with microglia in protecting neurons from toxic substances
MICROGLIA
o Protects the CNS from foreign matter (i.e. bacteria, dead or injured cells) by using
phagocytosis and the release of cytokines. Also protect against oxidative stress.
GLIAL CELLS IN NEURODEGENERATIVE DISEASES
o Multiple sclerosis (autoimmune disease) results from the loss of myelin in the CNS. This
slows down communication (i.e. blurred vision, muscle weakness, etc).
o Alzheimer’s disease is caused by the loss of cholinergic neurons, and replacement of lost
neurons with scar tissue (plaques). Astrocytes and microglia release inflammatory
chemicals that enhance the degeneration of cholinergic neurons.
o Parkinson’s disease is a degenerative disease involving the loss of dopaminergic
neurons. Similar to Alzheimer’s disease.
PHYSICAL SUPPORT OF THE CENTRAL NERVOUS SYSTEM
The outermost structures that protect the soft tissues of the CNS are the bony skull (cranium),
which surrounds the brain, and the bony vertebral column, which surrounds the spinal cord.
Between the bone and the nervous tissue are 3 membranes called the meninges and a layer of
fluid called cerebrospinal fluid, which provide protection against impact.
Meninges: 3 connective tissue membranes that separate the soft tissue of the CNS from the
surrounding bone (dura mater, arachnoid mater, pia mater).
Dura mater: outermost layer, closest to the bone; very tough fibrous tissue.
Arachnoid mater: middle layer; web-like structure.
Pia mater; innermost layer; immediately adjacent to the nervous tissue.
Subarachnoid space: the space between the pia and the arachnoid filled with cerebrospinal fluid.
Cerebrospinal fluid (CSF): clear, watery fluid that bathes the CNS. Surrounds the CNS and fills
cavities within the brain and spinal cord. Acts as a shock absorber and interstitial fluid that
bathes neurons and glial cells. Maintains neural ionic composition around neurons for normal
excitability. Needs to be replenished by the blood supply to the CNS.
The brain contains 4 cavities called ventricles which are continuous with each other: 2 C-shaped
lateral ventricles are connected to a midline 3rd ventricle by the interventricular foramen. The

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9 THE NERVOUS SYSTEM: CENTRAL NERVOUS SYSTEM
cerebral aqueduct connects the 3rd ventricle to the 4th ventricle, which is continuous with the
central canal (long thin cylindrical cavity that runs the length of the spinal cord).
The lining of the ventricles and central canal is composed of glial cells called ependymal cells
(type of epithelial cell). The lining of vascularized and forms a tissue called the choroid plexus
(have pia mater, capillaries, and ependymal cells), and helps with the synthesis of CSF.
Total volume of CSF is 125-150mL, but is recycled 3x a day therefore 400-500mL/day.
CSF is circulated throughout the ventricular system and enters the subarachnoid space through
openings of the fourth ventricle. CSF in the subarachnoid gets reabsorbed into venous blood
through structures in the arachnoid mater called arachnoid villi at the top of the brain.
BLOOD SUPPLY TO THE CNS
CNS accounts for only 2% of the body weight but receives 15% of the blood that the heart pumps
at resting conditions.
CNS has a high metabolic rate, thus high demand for fuel and oxygen to meet its energy needs.
The brain accounts for 20% of all the oxygen that the body consumes, and 50% of all the glucose
consumed.
The CNS is sensitive to interruptions in blood flow because cells in the CNS have very little
glycogen and no access to fatty acids, therefore must obtain glucose directly from the blood.
Nervous tissue can’t obtain energy from anaerobic metabolism, so it requires an uninterrupted
supply of oxygen and glucose to stay alive.
CNS tissue can also use ketones to supply up to 2/3 of their energy needs. Ketones are a by-
product of lipid catabolism when glucose supplies are limited.
BLOOD-BRAIN BARRIERS
The exchange of oxygen, glucose, and other materials between blood and cells in the CNS occurs
across the walls of capillaries.
Capillary walls are composed of a single layer of endothelial cells, providing a short diffusion
distance exchange for small molecules (gases, inorganic ions, monosaccharides, amino acids).
Hydrophobic molecules diffuse across the membranes of the endothelial cells, whereas
hydrophilic molecules diffuse through relatively large gaps between the endothelial cells.
Marcomolecules can be actively transported across the endothelial cells by transcytosis
(movement of molecule across an endothelial cell by endocytosis into the cell followed by
exocytosis out of the cell).
Transcytosis doesn’t occur across capillary endothelial cells in the CNS, and the movement of
hydrophilic molecules across capillary walls because it’s restricted by the blood-brain barrier.
Blood-brain barrier: a physical barrier that exists between the blood and CSF, which is the
interstitial fluid in the CNS. Due to the presence of tight junctions between the capillary
endothelial cells, which eliminate capillary pores and thereby restrict the diffusion of hydrophilic
molecules between the cells.
Astrocytes are vital for the blood-brain barrier in that they stimulate endothelial cells to develop
and maintain tight junctions.
Gases and other hydrophobic molecules penetrate through these cells easily because they are
able to move across by simple diffusion through the lipid bilayer. Hydrophilic substances rely on
mediated transport, which makes the blood-brain barrier selectively permeable.
Glucose is transports across the barrier by GLUT-1 carriers.
Receptors for insulin are located on neurons in the CNS (i.e. in the satiety center of the
hypothalamus). Helps with the regulation of food intake (satiety hormone), not glucose
metabolism.
GREY MATTER AND WHITE MATTER
The central nervous system has an orderly arrangement of neurons such that sell bodies,
dendrites, and axon terminals tend to be found in clusters that appear gray and axons appear in
clusters that appear white (grey matter and white matter).
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