PSL300H1 Lecture Notes - Lecture 4: Metabotropic Receptor, Adenylyl Cyclase, Muscarinic Acetylcholine Receptor
Document Summary
If you phosphorylate membrane proteins (i. e. ion channels) results in modulation of ion current: extra steps with the involvement of 2nd messengers, the metabotropic receptor activation takes time. Ligands for metabotropic receptors: ach: muscarinic receptor (leads to ionotropic effects but in muscles metabotropic effect, peptides: substance p, b-endorphin, adh, catecholamines: noradrenaline, dopamine, serotonin, purines: adenosine, atp, gases: no, co. Spread of psps: psps are generated in inexcitable membrane: neuronal dendrites and cell bodies (these areas do not have high density of voltage-gated. Psp summations: biological tissues have poor cable property (compared to telephone cables, thus, there will be loss of. This is not a trigger zone (no ap) Lose some voltage here current (potential) as you go along the membrane before reaching the trigger zone. If you want to kill a really big elephant, how can you do it: all of your friends together, surround elephant and poke elephant at the same time, three excitatory neurons fire.
