PSL300H1 Lecture Notes - Lecture 4: Bone Resorption, Bone Remodeling, Manitoba Highway 10
Document Summary
Essential roles of ca2+ in systems physiology. Recommended daily dietary intake: 1000 mg = 25 mmol/l. Symptoms: tingling in hands or feet, unusual muscle jerking/cramps/twitching tiredness, irritable, depressed (in extreme cases muscle tetany of respiratory muscles & asphyxiation) Symptoms: increased thirst (because body trying to excrete excess) Kidney & gall stone formation (in extreme cases loss of consciousness and coma) [matrix from which calcium phosphate is deposited ] Osteoclasts more active than osteoblast after age 30. Be more active - more weight-bearing exercise such as running, fast walking. Osteoporosis: takes longer to heal fractured bone because calcium is inactive. Responding to stimulation of the other cell type. Ob stimulated by pth (cid:314) release rankl stimulating factor. As a single cell is not able to digest bone. Rank ligand increase the activation of osteoclast and they begin to digest bone . Calcitriol induces ca transporter, and calbinding 9k.
