PSL300H1 Lecture Notes - Lecture 3: Adenylyl Cyclase, Estrogen Receptor, Insulin Receptor
Document Summary
Textbook reading: silverthorn 6th ed 181-188, 193-195; 4th ed. Thyroid stimulating hormone = 10miu/l (normal range = 1 4. 5miu/l) Located in cell membrane, cytoplasm, nucleus high affinity for specific ligand. Variable number in target cell (500 -100,000) Receptors bind, and then release the ligand. Zinc helps position the estrogen to the receptor. The receptor forms a u-shape, important for binding dna. If the conformation is not changed, there will be no binding to dna. Every receptor have a different 3d structure, which determined what happens when bound. In the cytosol once hormone bound translocate from cytosol to nucleus. Both will interact with dna and change transcription. Directly alter gene transcription = genomic effects. Bind lipid soluble hormones (steroid, thyroxine ) Intrinsic enzyme activity - they are enzyme, they don"t need other enzyme to activate. Changes the conformation and activity of the receptor. Alters the activity of intracellular signaling pathways.
