PSL300H1 Lecture Notes - Lecture 18: Exocytosis, Antidromic, Vasodilation
Document Summary
Energy input from the environment changes membrane potential: usually depolarize, except 1 type of neuron hyperpolarizes. Changes in membrane proteins: changes the physical shape of the neuron opens cation channels, activate gpcr secondary messenger (camp, cgmp, ip3) & amplify signals. Ligand-binding adenylyl cyclase camp production camp effects: Transmission: phosphorylates proteins, directly interact with ion channel membrane depolarization. Amplification: gpcr g-protein can activate many enzymes (multiple adenylyl cyclases, or multiple different enzymes, secondary messenger produces many camp molecules. Nasal cavity w/ mucosal membrane: olfactory nerve innervates the mucosal membrane. Specific odour molecules bind to specific receptors. Signal summates ap produced (or not) Membrane depolarized depolarization travels down to end of cell release vesicles: no action potential produced, small cells size of the cell > length constant. Ca2+ channels open at terminal button triggers exocytosis. All of the depolarizations (electrical changes in receptor cells) receptor potentials.
