PSL300H1 Lecture Notes - Lecture 24: Proopiomelanocortin, Signal Peptide, Adrenocorticotropic Hormone
Document Summary
Protein hormones (usually protein hormones on exam) Made in advance; stored in vesicles ready to be released when there is a signal (exocytosis) Water soluble cannot pass the cell membrane (ie. we must have a receptor on the cell membrane) Can be made in different places in the body. They care chemicals made by cells in specific endocrine glands or other tissues. Transported in the blood to distant targets. Maintain homeostasis or precipitate change in many physiological processes. Preprohormone (signal peptide - brings it into the er & gets cleaved off - , active protein and inactive protein) One preprohormone can create multiple hormones (same copies of the same hormone or more than one type of hormone) Eg pomc one of them is acth (ie. if we want to increase. Acth, then we have to increase the concentration of all the other peptides coded by pomc)
