PSL301H1 Lecture Notes - Lecture 3: Innate Immune System, Adaptive Immune System, Natural Killer Cell
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PSL301H1 Full Course Notes
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Types of pathogens, defense: components of the immune system, innate immune systems. Leon: presents with cough and diarrhea, fatigue and aches, headaches and stiff neck. Reddish-purple discoloration on chest, red throat, enlarged tonsils. Leon is suffering from meningitis (neisseria meningitidis; meningococcus bacteria) Post-diagnosis: leon has history of meningitis in hs, 3/5 siblings were also affected by meningitis. May have defect in complement system, orders ch50 complement test and genetic test. Result: mutation in c8, indicating complement is non-functional. Fever cause: pyrogens change the thermoreg set point in hypothalamus, inc temperature. Need to gain entry into our cells (host) to bring dna to implant itself and replicate. Codes for capsid proteins, and the dna for assembly and transmission. Need a mechanism to kill virally infected cells. Always there and attempts to remove the pathogen as quickly as possible. Those with poor innate systems do not live well or may die early. Mucous secretion, lysozyme, and stomach acid is included in this.
