PSL301H1 Lecture Notes - Lecture 28: Argininosuccinate Synthase, Carbamoyl Phosphate, Collecting Duct System
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PSL301H1 Full Course Notes
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Nitrogenous wastes, urea, and uremia: end stage kidney failure: combining balances. See case of the day: endocrine functions of the kidney. This lecture will not be on the mar 22 midterm 2, however it does summarize and touch upon a concepts from previous lectures. Recommend to give it a quick review before the midterm. End stage kidney failure: can"t live without regular dialysis. Diabetes is the most common cause of this in north america. Est that by 2025, china will have 200+m diabetics. 65 yo male, lives alone, diabetic for 25y. Presents in er with complaints of severe fatigue/weakness. Poor appetite, nausea, vomiting, swelling of feet/ankles, itching. Poor memory and confusion, difficulty sleeping, muscle twitches. Physical: edema and bp 180/110, pale, breath smells of urine. Pt has severe kidney failure with gfr < 15 ml/min (10-20% of regular) Severe fatigue and weakness: anemia due to reduced epo secretion from damaged kidney, leading to reduced o2 carrying capacity of blood.
