PSL301H1 Lecture Notes - Lecture 1: Fibrin, Pernicious Anemia, Colony-Stimulating Factor

• School: UTSG
• Department: Physiology
• Course: PSL301H1
• Professor: Michelle French

Document Summary

Lecture 1- introduction to blood and the red blood cell. Hematocrit: % of rbc / total blood volume. The percentage of blood volume that is packed red blood cell. In men higher hematocrit: testosterone increases rbc production. Ions: mostly made by the liver, albumins, globulins, fibrinogen. Buffers ph: amino portions of proteins interacts with free h+ ions, determines the concentration of free h+ = buffer. Albumin: carrier: regulates colloid osmotic pressure. Globulins (3 types): clotting, enzyme, carrier ( ,(cid:533), antibodies ((cid:534)) Fibrinogen: clotting: precursor for clotting factors, fibrinogen broken into fibrin blood clot. Cells: red blood cells (ie. erythrocytes) [99. 9%, white blood cells (ie leukocytes) [0. 1%, granulocytes (basophils, eosinophils, neutrophils, granular morphologies, phagocytes (neutrophils, monocytes, phagocytoses foreign molecules. Abnormalities may indicate a cancer of the blood cells. Biconcave disk, formed by its cytoskeleton: allows it to fit through thin capillaries. No nucleus present: cannot live forever & regenerate the necessary proteins. No mitochondria present only anaerobic metabolism.