PSL301H1 Lecture 4: Lecture 4- Acquired Immunity Cont.
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PSL301H1 Full Course Notes
Verified Note
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Document Summary
Activation of t cells: helper t cells (cd4, cytotoxic t cells (cd8) Binding: cd4 surface molecule, binds mhc class 2 molecules. Function: releases cytokines increases immune response (t & b cells) Binding: cd8 surface molecule, mhc class 1 molecules. Found on: dendritic cells, macrophages, b cells. Presents exogenous antigen (breakdown antigen & present fragment: endocytosis, breakdown, fusion of fragment & mhc, presentation. Co-activation (mhc-class 2 & cd4 surface proteins) creates fuller activational response. Effect: helper t cell division, divide into active helper t cells (short-lived, divide into memory t cells, cytokine release, activates, helper t cells, cytotoxic t cells, b cells. Found on: all nucleated cells (ie most cells: not red blood cells. Presents endogenous antigen (endocytosis, cell produces the antigen: ex. Viral proteins: viral dna makes viral proteins, viral proteins fuse w/ mhc class 1 on er presentation, ex. cancerous cells, ex. dendritic cells.
