PSL301H1 Lecture Notes - Lecture 2: Mast Cell, Antigen Presentation, Phagocyte
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PSL301H1 Full Course Notes
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Document Summary
Lymph nodes: part of lymphatic circulation, clustered cells intercept pathogens. Spleen: immune cells monitoring blood, phagocytes to remove aging rbcs. Encapsulated tissues: contained tissue with outer wall of fibrous collagenous capsule. Unencapsulated tissues: diffuse in tissue, intercept pathogens before circulation. Immune system: destroys pathogens, detects/kills abnormal cells, removes cell debris: different intracellular/extracellular pathogens i. e. parasite, fungi, protozoa, bacteria, virus. Antibodies: proteins secreted by immune cells that bind antigens to make them visible. Innate immunity: rapid, non-specific, present from birth: membrane receptors with broad specificity. Primary lymphoid tissues: where immune cells form and mature. Secondary lymphoid tissues: mature cells interact with pathogens, initiate response. Lymphatic system: transports pathogens/dendritic cells to lymph nodes: return excess tissue fluid/fat from digestive system to blood, specialized organs contain mature immune cells, interact with pathogens (immune response) Leukocytes: primary immune cells, circulate but mostly function extravascularly: use granules (granulocytes), phagocytosis (phagocytes), foreign proteins (antigen-presenting) Neutrophils: phagocytic, ingest/destroy invaders, release cytokines most abundant wbc.
