PSL301H1 Lecture Notes - Lecture 1: Dominance (Genetics), Cystic Fibrosis, Epithelial Sodium Channel

• School: UTSG
• Department: Physiology
• Course: PSL301H1
• Professor: Christine Wong

Document Summary

Lecture 1 the respiratory system and breathing. Clinical focus: cystic fibrosis v definition: a genetic disease that causes. Because of digestive tract problems: salty tasting skin, increased mucus in lungs, nasal congestion, pneumonia. Common because the capacity of the airways we eliminate pathogen is compromised v image: x-ray: shows diffuse interstitial disease. One of the symptoms of cystic fibrosis: the large white area is the accumulation of mucus. Makes the cells a bit bigger and inflamed. This reduces water secretion in the airway v image: normal airways vs airways with cystic fibrosis: normal airways. Normal layers of tissue and muscle fibers. Accumulation of mucus causes infection and inflammation of the walls. Transport is difficult v cystic fibrosis is due to a defective cystic fibrosis. These two transporters regulate ions that in turn regulate water transport: in cystic fibrosis, the cftr is missing. No chloride regulation, and therefore no water regulation.