PSL301H1 Lecture 10: Cardiovascular Lecture 7 (10)

• School: UTSG
• Department: Physiology
• Course: PSL301H1
• Professor: French, Gramolini, Richardson, Wong

Document Summary

Lecture 7: cardiovascular system regulation of blood flow. Microcirculation: arterioles, capillaries and venules, form the microcirculation. Sinusoids are 5x wider than a capillary. Sinusoid endothelium has fenestrations and may have gaps between the cells. Sinusoids are found in locations where blood cells and plasma proteins need to cross the endothelium to enter the blood. Most capillary exchange takes place by diffusion and transcytosis: exchange between the plasma and interstitial fluid takes place either by. Movement through the junctions between endothelial cells (the paracellular pathway) Movement through the endothelial cells (endothelial transport: smaller dissolved solutes and gases move by diffusion between or through the cells depending on their lipid solubility. In most capillaries, large molecules are transported across the endothelium by transcytosis (endocytosis vesicular transport exocytosis) In some capillaries, chains of vesicles fuse to create open channels that extend across the endothelial cell: diffusion. The most important means by which substances are transferred between plasma and interstitial fluid is by diffusion.