PSL350H1 Lecture 7: PSL350 Lecture 7
15 Mar 2016
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Psl350 - protein targeting mechanisms in cells (lecture 7) Central dogma of molecular biology: dna rna (transcription) protein (translation) Questions to consider: how do proteins get trafficked within a cell, how can we assess protein changes in the cell. I-cell disease (mucolipidosis ii) caused by defect in lysosomal targeting. Many hydrolytic enzymes fail to be targeted to lysosomes and are secreted from cells. Proteins all have a rate of turnover, along with machinery making new proteins and degrading old ones, if these recycled proteins don"t get to the lysosome then it causes havoc in the body. Average life span ~ 8 years: zellwenger syndrome. Peroxisomal targeting defect peroxisomes reclaim old molecules (defects are not within nuclei/er but inability to reprocess old things) If it goes to the golgi, it needs to be transcribed, translated and then finished at the rer to be transported to the golgi (for final destination through the plasma membrane or lysosome)
