Ap arrives at terminal button and change in polarization of membrane changes calcium channels calium rushes into cell and interact with proteins and vesciles fuse with membrane and spill vesicles into synaptic clept. One way nts are removed form synaptic cleft. But also by post and glial cells. In order to reg nt and function of pre reg feedback serves as message to pre to increase or decrease release. Pre syn receptors are protein that sit on membrane of pre and. Pre syn button and post neuron and receptors sitting on pre membrane nts released by post and bind to pre receptors and produce some change in terminal button that affects neural transmission. Dendritc branch not all machinery for release of nt so this is not calcium dependednt. Protein in membrane membrane transporters that bind to receptor in post and through some change that with bring nt into cleft intracellular then to extracellulr.