PSY493H1 Lecture Notes - Lecture 7: Sensory Cortex, Sensory Memory, Explicit Memory
Document Summary
Integrated signals enter through entorhinal cortex perforant pathway dentate gyrus (dg) hc. Phases of ltp: ltp occurs in 3 major steps, induction: occurs when stimulation can produce an increase in synaptic strength, expression: if there is an increase in synaptic strength, maintenance: the steady state level of increase. Hc from first principles: from lesion studies such as hm, we know that hippocampus is important in memory formation, we also know that the hippocampus is important for storing or retaining memories for several weeks before it gets. Encoded elsewhere in the cortex: must get the relatively short-term (ltp enhanced memory) from the hippocampus to different areas of the cortex, hippocampus stores memories only for short periods of time (weeks) After induction of ltp, new spines appear on the ca1 pyramidal cell dendrites: potentiation of the synaptic response (ltp) by 80% 13% increase in spine density, this change is prevented by prevented by nmda-r antagonists.
