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PSY396 MAY 27.docx

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PSY396 MAY 27, 2013 Drug receptor interactions - Natural ability of enzyme to sepnd time in resting or active state - Receptor can be either resting closed or active where channel is open receptor switches between them - Equilbirum leans to resting inactive or closed state however some receptors in more active state which is rarity, they exist - Most recpetors in inactive - Bindgn nt shifts eq from inactive to inactive - Agoisnitys open more Next - Resting state and active state between two conformational states equ shifted to resting however as Is receptor is active and producing some effect - Drug shift one way or another - Add drug agonist eq from rest move to active induce stronger biological effect - Shift applies to agonist drug Next - Inverse to rest - Antagonist not shift eq but atagosnit come to play when natural agonist trying to bind to receptor sites - Inverse to resting state or being closed as opposed to active state - Antagonist original eq stays same Cns - Posterior is cerebellum not test on Bbb - Protect from harmful molecules from entering brain - Capsule selects what chemicals get to the brain - Semipermeavble - Perm to some but large molecules can cross - Also low solubility in fat bc need to cross several membranes that are fat - Charged not pass - Main component of bbb is glial cells Nts - Dop and nore - Indo is sero - A lot on these three - Heavily involved in neurompdulators - Glu and gaba – serve as nt - Most widespread – glut primary ecitary and gaba primary inh - Peptides- sub p or endongeonous opiods Classifiying - Some nts neurotransmission is mediated through met some both receptors - Not know tables - Know receptor subtypes later on - When talking about function of nt difficult to anticapte what will happen not know what receptor drug bind to - Yet uncover all details and large variety of receptors Ach - Amine - Widespread in brain and peripheral nervous system - Periphery drivces both smoth and striatal muscles - Work on own and control consciously - Ach present in neur muscle junction mediator between cns and muslo - Ach in brain - Two main centers - Dorsalateral pons and basal forebrain - Cholinergic – primary is ach Ach - Two centers of ach - Dorsolater – to low brain areas main function related to rem sleep or initation of it - The nuc baseles – basal forebrain – innverates neo cortex and hipp and amygdala - Involved in addiction, learning attention memory - Brain cell bodies situated and axons or targets widespread across brain Rat brain - Internrons are localized in one brain area with little long projection - Not need to know except metioned latter Synthesis - In chol cells - Enzume choline trans – brings choline and coenzyme a to create ach - While release co enzyme a as byproduct - How much is how much constituents - Limiting substrate is choline – which is injested through diet and some recycled ach is broken up - Without reuptake amount will decrease Synt and degradaition - Ach broken to acetic acid and choline and diff enzyme Ach - Should know - Abundant in peripheral and muscle contraction - Cns plays role in attention learning - Enzyme in synaptic cleft bound to pre and post membrane – esterase Ach receptors - Ach mediates nt though 2 types of receptors - Nic and muscarinic named bby agonist drugs - Nicotinic are ion - 5 sub are 14 all combine in different ways - Alpha 4 – alpha 4 and beta 2
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